Iodine is one of those trace minerals we don’t often think about—until something goes wrong. Yet this small but mighty nutrient plays a crucial role in one of the body’s most important systems: the thyroid. Without iodine, the thyroid can’t function properly, and that affects everything from metabolism to brain development. In this first article in the Iodine Series, we’ll explore what iodine does in the body, why it matters across the lifespan, and how even mild deficiencies can have lasting consequences.
The Core Role of Iodine: Thyroid Hormone Production
The primary role of iodine in the human body is to help make thyroid hormones—mainly thyroxine (T4) and triiodothyronine (T3). These hormones are made by the thyroid gland, a small butterfly-shaped gland at the base of your neck.
Thyroxine (T4) contains four iodine atoms.
Triiodothyronine (T3) contains three iodine atoms.
These hormones regulate nearly every system in the body. Without adequate iodine, your thyroid simply cannot produce T3 and T4 in sufficient quantities.
How Thyroid Hormones Affect Your Body
Thyroid hormones play a central role in metabolism, but their influence reaches far beyond energy levels. Here’s how they help keep you healthy:
Control basal metabolic rate (BMR) – influencing how your body uses energy
Regulate body temperature
Support brain and nervous system development (especially during pregnancy and infancy)
Maintain heart rate and muscle function
Support reproductive health and menstrual balance
Influence cholesterol levels and glucose metabolism
Iodine and Brain Development: Why Early Life Matters Most
Iodine is especially critical during pregnancy and infancy. It supports:
Fetal brain development
Formation of the nervous system
Cognitive performance in early childhood
Even mild iodine deficiency during pregnancy can impair the baby’s mental development. That’s why global health authorities emphasize iodine sufficiency in women of childbearing age and children under five.
Consequences of Iodine Deficiency
When the body doesn’t get enough iodine, the thyroid struggles to produce hormones. This can lead to:
Goiter – an enlarged thyroid gland
Hypothyroidism – fatigue, weight gain, cold sensitivity, constipation
Cognitive delays in infants and children
Pregnancy complications – including miscarriage, stillbirth, and intellectual disability in the baby
Cretinism – a rare but severe form of iodine deficiency with profound mental and physical developmental issues
Summary Table: Iodine’s Core Functions
Function
How Iodine Helps
Thyroid hormone production
Essential component of T3 and T4
Brain development (fetal & infant)
Supports growth of brain and central nervous system
Metabolism
Regulates energy usage and body temperature
Reproductive health
Supports hormonal balance and pregnancy outcomes
Growth and development
Promotes physical and cognitive development
Conclusion:
While iodine may not make daily headlines, it remains one of the most essential nutrients for human development and hormonal balance. And because our bodies can’t make it on their own, we need to get it from our diet every day.
Iodine is essential — but like all nutrients, too little or too much can both cause harm. That’s why maintaining a healthy iodine balance is crucial for thyroid function, brain development, and metabolism. In this second article, we’ll break down the key signs of iodine deficiency, what happens when your body gets too much iodine, and how to spot potential red flags before they turn into long-term health concerns.
Recognizing Iodine Deficiency
Iodine deficiency is one of the most common preventable causes of intellectual disability worldwide and still affects certain populations, especially in areas with low iodine in soil and water.
Common Symptoms of Iodine Deficiency:
Fatigue and sluggishness
Weight gain
Feeling cold more easily
Constipation
Dry skin
Hair thinning or hair loss
Slow heart rate
Menstrual irregularities
Difficulty concentrating (“brain fog”)
Depression or mood swings
Many of these symptoms overlap with hypothyroidism, because iodine deficiency often leads to reduced thyroid hormone production.
Iodine Deficiency in Pregnancy and Childhood
This is where iodine’s impact becomes even more serious.
When iodine is lacking during pregnancy or infancy, the consequences can be long-lasting:
Impaired cognitive development
Delayed motor function
Reduced IQ
Hearing loss or speech difficulties
Increased risk of miscarriage or stillbirth
In severe cases, chronic deficiency can lead to cretinism, a condition marked by profound physical and mental impairment.
What Is Goiter?
One of the most visible signs of iodine deficiency is goiter — a swelling of the thyroid gland in the neck. It occurs when the thyroid tries to compensate for low iodine by enlarging in an attempt to absorb more from the bloodstream.
Can You Get Too Much Iodine?
Yes. While deficiency is more common globally, excessive iodine intake—usually from over-supplementation or high-iodine foods in large amounts—can also disrupt thyroid health.
In some cases, high iodine intake can trigger autoimmune thyroid disorders, such as Hashimoto’s thyroiditis or Graves’ disease, especially in people with pre-existing thyroid issues.
Summary Table: Signs of Iodine Imbalance
Condition
Common Signs & Symptoms
Iodine Deficiency
Fatigue, weight gain, goiter, cold sensitivity, dry skin, poor concentration
The thyroid is incredibly sensitive to iodine levels. Too little iodine and it slows down. Too much, and it may go into overdrive or shut down altogether. Finding the right middle ground—getting just enough but not too much—is the key to protecting your hormonal health.
Once iodine enters your body—whether through food, water, or supplements—it begins a complex and highly regulated journey. From the digestive system to the thyroid gland, every step of iodine’s path is finely tuned to support hormone production without tipping into excess. In this article, we’ll explore how your body absorbs iodine, how it uses and stores it, and what can influence how much of that iodine is actually available to your cells.
Iodine Enters Through the Digestive Tract
Most dietary iodine comes in the form of iodide (I⁻), a soluble and easily absorbable form of iodine. Once you consume iodine-containing foods, it is absorbed:
Primarily in the stomach and upper small intestine
Very efficiently — about 90% of dietary iodide is absorbed
From there, iodide enters the bloodstream and is rapidly taken up by various tissues—especially the thyroid gland, which uses it to produce hormones.
The Thyroid: Iodine’s Main Destination
The thyroid gland is the body’s iodine reservoir. It absorbs iodine from the blood through a specialized transporter called the sodium-iodide symporter (NIS).
Inside the thyroid:
Iodide is oxidized and bound to the amino acid tyrosine.
These modified tyrosines combine to form T3 and T4, the body’s primary thyroid hormones.
The gland stores several weeks’ worth of iodine, giving it a buffer against short-term fluctuations in intake.
Regulation by TSH (Thyroid-Stimulating Hormone)
Iodine absorption and use are controlled by the thyroid-pituitary feedback loop:
The pituitary gland releases TSH (thyroid-stimulating hormone).
TSH signals the thyroid to absorb more iodine and make more hormones.
When T3 and T4 levels are sufficient, TSH production decreases.
When levels drop, TSH increases, pushing the thyroid to absorb more iodine again.
This feedback loop keeps iodine use responsive and adaptable, helping your body adjust to your metabolic needs.
Factors That Affect Iodine Bioavailability
While iodine is generally well absorbed, several factors can influence how much is actually usable in the body:
Nutrient Interactions:
Selenium is essential for converting T4 into the more active T3.
Iron deficiency can impair thyroid function and lower iodine efficiency.
Zinc supports the production of TSH.
Dietary Inhibitors (Goitrogens):
Certain compounds can block iodine uptake by the thyroid, especially when iodine intake is already low. These are found in:
Cruciferous vegetables (cabbage, kale, broccoli)
Cassava
Soy-based foods
Note: Cooking these foods significantly reduces their goitrogenic effects. For most people with adequate iodine intake, these foods do not pose a problem.
Environmental and Lifestyle Factors
Soil iodine levels: Populations in iodine-poor regions are more likely to have deficiencies, especially where food isn’t fortified.
High nitrate exposure (from drinking water or fertilizer) may interfere with iodine uptake.
Smoking: Contains thiocyanate, which competes with iodine for uptake in the thyroid.
Pregnancy and lactation: Increase the body’s iodine requirement due to higher hormone production and fetal development needs.
Summary Table: Iodine Absorption and Influencers
Step
What Happens
Absorption
Iodide absorbed efficiently in the stomach and small intestine
Transport
Carried in blood to the thyroid via the sodium-iodide symporter
Use
Converted into thyroid hormones (T3 & T4)
Regulation
Controlled by TSH from the pituitary gland
Influencing Nutrients
Selenium, iron, and zinc support iodine metabolism
Inhibitors
Goitrogens (in some foods), smoking, nitrates
Increased Needs
Pregnancy, lactation, and certain medical conditions
Conclusion:
Iodine’s story doesn’t end with absorption—it’s how it interacts with the rest of the nutrient ecosystem and lifestyle choices that truly shapes its impact. In the final article of this series, we’ll dive into the top iodine-rich foods, both animal and plant-based, and how to meet your needs without going overboard.
Getting the right amount of iodine starts with the food you eat. Whether you’re following a plant-based lifestyle or enjoy a more omnivorous diet, there are excellent sources of iodine to support healthy thyroid function and overall metabolism. This final article in the iodine series introduces the most iodine-rich foods, the factors that influence how much iodine they deliver, and how to maintain a safe daily intake without tipping into excess.
Iodine in Nature: Why It’s Unevenly Distributed
Iodine is most abundant in seawater, coastal soil, and marine life. Inland and mountainous areas tend to have iodine-depleted soil, which means fewer natural iodine sources — unless foods are fortified or iodine-rich products are imported.
Animal-Based and Plant Based Iodine Sources
These are among the richest and most reliable sources of iodine. They are especially important in regions without iodized salt or where plant-based options are limited.
Plant-based eaters can absolutely meet their iodine needs — but must do so more intentionally, especially without access to fortified products.
Caution: Seaweeds like kelp, kombu, and wakame can contain excessively high levels of iodine. Even small amounts can lead to iodine excess, especially if consumed daily. Nori (used in sushi) is lower and safer for frequent use.
Tips to Maintain Iodine Balance
Use iodized salt in moderation. Just ¼ teaspoon daily covers most needs.
Avoid doubling up on iodine-rich foods and supplements unless medically advised.
Check labels on plant-based milks or seaweed snacks for iodine content.
Rotate seaweed types, and limit kelp or kombu to occasional use.
During pregnancy and breastfeeding, iodine needs are higher — discuss supplementation with your healthcare provider.
Summary Table: Iodine Food Sources
Food Group
Examples
Considerations
Seafood
Cod, shrimp, tuna
Reliable and concentrated iodine sources
Dairy
Milk, yogurt, cheese
Varies with farming practices
Eggs
One egg provides ~24 µg
Accessible and nutrient-rich
Seaweed
Nori (moderate); kelp (very high)
Monitor intake to avoid excess
Iodized Salt
¼ tsp = 76 µg
Best used in small, controlled amounts
Fortified Foods
Plant milks, some breads
Read labels to verify iodine content
Vegetables & Beans
Potatoes, navy beans, cranberries
Contain small but helpful amounts
Conclusion:
Iodine is both essential and powerful. Whether you’re aiming to support thyroid health, planning for pregnancy, or simply balancing a nutrient-dense diet, knowing where to find iodine in your food matters. And as with all nutrients—especially those affecting hormones—balance is the key.